This paper investigates determinants of innovation in MENA (Middle East and North Africa) countries. This investigation focused on GDP per capita (PPP), higher education enrollment, economy openness, business disclosure and unemployment rates, among other factors. The analysis uses the Global Innovation Index (GII), patent applications and high technology export as dependent variables in separate models. Panel regression is applied in the study. The result indicates that in the MENA region, all the above four factors except unemployment rate are determinants of innovation, and it is also shown that high technology export is the best proxy for innovation among the three dependent variables. This study is organized in the following format: introduction, followed by literature review, then data and methodology, then the results and discussion; finally, the paper closes with its conclusion and potentialities for future research.